Gemcitabine-induced neutrophil extracellular traps via interleukin-8-CXCR1/2 pathway promote chemoresistance in pancreatic cancer
Our findings reveal that NETs contribute to chemoresistance in PDAC and that IL-8-mediated chemoNETosis plays a pivotal role in this process. Inhibition of CXCR1/2-mediated NET formation enhances the efficacy of GEM. This approach may represent a promising therapeutic strategy for overcoming chemoresistance in PDAC. These results support further clinical investigation of anti-NETs therapies.
Authors
- Kazuya Yasui
- Hiroshi Tazawa (ORCID: https://orcid.org/0000-0003-4658-1050)
- Atsuki Taniguchi (ORCID: https://orcid.org/0000-0003-2908-9056)
- Nobuhiko Kanaya (ORCID: https://orcid.org/0000-0002-0427-4426)
- Shinji Kuroda (ORCID: https://orcid.org/0000-0002-4484-1253)
- Yoshiyasu Kono (ORCID: https://orcid.org/0000-0002-4717-5196)
- Satoru Kikuchi (ORCID: https://orcid.org/0000-0002-7671-0696)
- Yoshihiko Kakiuchi (ORCID: https://orcid.org/0000-0003-4886-2307)
- Shunsuke Kagawa (ORCID: https://orcid.org/0000-0002-3610-8211)
- Toshiyoshi Fujiwara (ORCID: https://orcid.org/0000-0002-5377-6051)
- Fuminori Teraishi (ORCID: https://orcid.org/0000-0001-5133-2644)
- Kosei Takagi (ORCID: https://orcid.org/0000-0003-2267-2441)
- Tomohiko Yagi
- Shohei Nogi
- Tomokazu Fuji (ORCID: https://orcid.org/0000-0002-7107-6518)
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1038/s41416-025-03192-1
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Japan Society for the Promotion of Science