Additive-free synthesis of α-keton thiol esters <i>via</i> oxyacylthiolation of vinyl azides with thioacids and water
An additive-free strategy has been developed for the synthesis of α-keton thiol esters through direct oxyacylthiolation of vinyl azides with thioacids and water. The C-S and CO bonds were formed in a one-pot operation <i>via</i> a radical reaction pathway. A number of α-keton thiol esters could be efficiently obtained in good yields with broad substrate scope and good functional group tolerance.
Authors
- Fei Jia (ORCID: https://orcid.org/0000-0002-2754-6009)
- Runmei Li (ORCID: https://orcid.org/0000-0001-6574-851X)
- Zi Yang (ORCID: https://orcid.org/0000-0002-8377-118X)
- Dong Yi (ORCID: https://orcid.org/0000-0002-8281-7860)
- Wei Wei (ORCID: https://orcid.org/0000-0002-0015-7636)
- Yingjie Wang (ORCID: https://orcid.org/0000-0002-6888-9542)
- Jian Huang
- Zuli Wang (ORCID: https://orcid.org/0009-0003-2695-8743)
Institutions
- Changsha Medical University (CN)
- Nanjing Forestry University (CN)
- Qufu Normal University (CN)
- Southwest Medical University (CN)
- Yan'an University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04878h
- Citations
- 6
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 5.62