Malignancy in Adults with Inborn Errors of Immunity: A Retrospective Single-Center Study
Findings confirm that NHL, particularly DLBCL, is the most prevalent malignancy in this cohort. Given the link between malignancies and underlying IEI, immunologic evaluation is recommended, particularly for NHL patients. The observed predominance of hematologic malignancies among CVID patients and the association with lymphoproliferation further emphasize the need for heightened malignancy surveillance and early immunologic workup in this subgroup. Further research on biomarkers for malignancy prediction in IEI is warranted.
Authors
- Melih Özışık (ORCID: https://orcid.org/0000-0002-2987-6933)
- Asude Durmaz (ORCID: https://orcid.org/0000-0002-4109-9401)
- Meryem Demir (ORCID: https://orcid.org/0000-0003-2915-6300)
- Semiha Özgül (ORCID: https://orcid.org/0000-0002-0220-1207)
- Ceyda Tunakan Dalgıç (ORCID: https://orcid.org/0000-0002-0318-3135)
- Gökten Bulut (ORCID: https://orcid.org/0000-0002-4735-0564)
- Ömür Ardeniz (ORCID: https://orcid.org/0000-0003-3804-2065)
- Nur Soyer (ORCID: https://orcid.org/0000-0002-7722-506X)
- Aytul Zerrin Sin (ORCID: https://orcid.org/0000-0002-9199-1991)
- Derya Demir (ORCID: https://orcid.org/0000-0002-6333-8856)
- Reyhan Gümüşburun (ORCID: https://orcid.org/0000-0002-0274-5917)
- Sinem İnan (ORCID: https://orcid.org/0000-0001-9708-7488)
- Asuman Çamyar (ORCID: https://orcid.org/0000-0002-9438-7300)
- Kasım Okan (ORCID: https://orcid.org/0000-0002-9743-4336)
- Ayça Aykut (ORCID: https://orcid.org/0000-0002-1460-0053)
- Onurcan Yıldırım (ORCID: https://orcid.org/0009-0006-2998-4877)
- Gülhan Boğatekin (ORCID: https://orcid.org/0000-0002-0695-7650)
- Hatice Serpil Akten (ORCID: https://orcid.org/0000-0002-3849-9367)
- Hasibe Aytac
- Funda Elmas Uysal
- Mehmet Soylu
- Metehan Karakoc
Institutions
- Ege University (TR)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s10875-025-01910-1
- Citations
- 2
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.59