Breaking the barrier: Transforming the diagnosis and management of penicillin and cephalosporin allergy in China
In this multicenter survey adjudicated from routine care, clinically-confirmed β-lactam allergy was substantially lower than self-report, and confirmed penicillin-cephalosporin cross-occurrence was uncommon (2.3%). Clear confirmation criteria and phenotype-based triage using existing documentation can support safe delabeling and more appropriate first-line β-lactam use; the accompanying standard operating procedure provides procedural detail for replication.
Authors
- Meiling Jin (ORCID: https://orcid.org/0000-0001-6532-3191)
- Xiaoyan Dong (ORCID: https://orcid.org/0000-0002-9656-7129)
- Xiaojian Zhou (ORCID: https://orcid.org/0000-0002-7710-1892)
- Shaoqing Yu (ORCID: https://orcid.org/0000-0003-2208-4535)
- Ranran Dai (ORCID: https://orcid.org/0000-0003-4044-2615)
- Haibo Ye (ORCID: https://orcid.org/0000-0001-9034-7013)
- Dylan Lee
- Shengan Chen
- Senlin Xu (ORCID: https://orcid.org/0000-0001-6625-5370)
- Chao Yuan (ORCID: https://orcid.org/0000-0002-4416-490X)
- Lin Lin (ORCID: https://orcid.org/0009-0006-5548-6492)
- Wei Dong (ORCID: https://orcid.org/0000-0002-8107-3900)
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Xiaobo Zhang (ORCID: https://orcid.org/0000-0002-4981-9565)
- Xiao‐Qing Zhao (ORCID: https://orcid.org/0000-0001-5558-8292)
- Li Ma (ORCID: https://orcid.org/0000-0001-7785-2007)
- Qiufang Qian
- Lanting Wang (ORCID: https://orcid.org/0000-0002-7070-6696)
- Yurong Gu (ORCID: https://orcid.org/0000-0002-5310-6699)
- Xiaoqun Luo (ORCID: https://orcid.org/0000-0002-0919-795X)
- Ling Yang (ORCID: https://orcid.org/0009-0009-4253-4012)
- Wanze Ni
Institutions
- Tongji University (CN)
- Royal Society of Medicine (GB)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- Jiading District Central Hospital (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Skin Disease Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
- Huashan Hospital (CN)
- Tongji Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.ijid.2025.108076
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00