The reticulocyte restriction: invasion ligand RBP1a of Plasmodium vivax targets human TfR1, prohibitin-2, and basigin
Our findings provide novel insights into the molecular mechanisms underlying reticulocyte restriction in <i>P. vivax</i>. The JK-1 and BEL-A cell lines represent valuable platforms for dissecting receptor-ligand interactions during parasite invasion and for advancing the development of targeted therapeutic antimalarial strategies.
Authors
- Markus Kalkum (ORCID: https://orcid.org/0000-0002-9506-671X)
- Monica Ararat‐Sarria (ORCID: https://orcid.org/0000-0002-5273-3260)
- Daniel Röth (ORCID: https://orcid.org/0000-0002-1190-3219)
- Jessica Molina-Franky
- Manuel A. Patarroyo (ORCID: https://orcid.org/0000-0002-4751-2500)
Institutions
- City Of Hope National Medical Center (US)
- Universidad Nacional de Colombia (CO)
- Fundación Instituto de Inmunología de Colombia (CO)
- City of Hope (US)
- Universidad del Rosario (CO)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1671048
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00