MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells
These findings suggest that FVIII-AnxA5 fusion proteins can engage apoptotic cell clearance pathways to facilitate antigen presentation in a potentially tolerogenic context. This strategy may offer a novel means of inducing immune tolerance to FVIII in hemophilia A.
Authors
- Arie J. Hoogendijk (ORCID: https://orcid.org/0000-0002-3082-2289)
- Chris Reutelingsperger (ORCID: https://orcid.org/0000-0002-2334-9403)
- Robin van Bruggen (ORCID: https://orcid.org/0000-0002-1676-0720)
- Mariarosaria Miranda
- Jan Voorberg (ORCID: https://orcid.org/0000-0003-4585-2621)
- Karin Fijnvandraat (ORCID: https://orcid.org/0000-0003-0904-4360)
- Maria Chiara Leoni (ORCID: https://orcid.org/0000-0002-3903-9848)
- Maartje van den Biggelaar
- Carmen van der Zwaan
Institutions
- Sanquin (NL)
- Maastricht University (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1668397
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00