Obesity metabolomics signature in children: associations with metabolic abnormalities and potential biomarkers
This study established a pediatric obesity-specific metabolomics signature (OB-MS), implicating oxidative stress, protein catabolism, and glucocorticoid metabolism in obesity-related metabolic abnormalities. These finding illustrate the metabolic mechanisms underlying the relationship between childhood obesity and metabolic abnormalities and provide new scientific support for early and precise prevention of metabolic abnormalities in children. Further longitudinal studies and experimental validation are warranted to elucidate its biological mechanisms and clinical utility.
Authors
- Wanzhen Zhong
- Guixian Tao
- Jiayi Wan (ORCID: https://orcid.org/0000-0003-0509-0298)
- Weiwei Zhang (ORCID: https://orcid.org/0009-0002-0536-9387)
- Jing Gu (ORCID: https://orcid.org/0000-0002-0744-5964)
- Yan Li (ORCID: https://orcid.org/0000-0003-4936-8917)
- Jie Huang (ORCID: https://orcid.org/0009-0006-1871-0598)
- Yujie Peng (ORCID: https://orcid.org/0000-0002-7034-5878)
- Jiaying Guo
- Chunzi Zeng
- Zhoubin Zhang (ORCID: https://orcid.org/0000-0003-4448-0758)
- Shiyun Luo
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fendo.2025.1671613
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Bureau