LTr1 alleviates DSS-induced ulcerative colitis by modulating macrophages to inhibit M1 polarization and associated inflammatory responses
These findings indicate that LTr1 exerts protective effects against DSS-induced colitis, at least in part by inhibiting macrophage infiltration and M1 polarization, thereby reducing pro-inflammatory cytokines production. This study provides a theoretical foundation for optimizing UC treatment strategies and highlights LTr1 as a promising candidate for the development of novel UC therapies.
Authors
- Wenjing Zhu (ORCID: https://orcid.org/0000-0003-0336-0063)
- Jia Xu (ORCID: https://orcid.org/0000-0002-0839-6690)
- Cheng Qian (ORCID: https://orcid.org/0000-0002-1392-6975)
- Jiacheng Qian
- Chang Liu (ORCID: https://orcid.org/0000-0002-5717-3370)
- Xinyuan Wang (ORCID: https://orcid.org/0000-0002-4129-2068)
Institutions
- National University of Ireland, Maynooth (IE)
- Open University of China (CN)
- Nantong University (CN)
- Trinity College Dublin (IE)
- Yancheng First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1651922
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00