Zinc deficiency as a contributor to acute kidney injury in patients with chronic kidney disease: a propensity score–matched retrospective analysis
Baseline zinc deficiency is an independent, modifiable risk factor for AKI development and mortality in patients with CKD. These findings support routine zinc status assessments and targeted supplementation strategies in CKD management protocols. However, the observational design and single-point zinc measurements limit the causal inferences. Prospective randomized controlled trials are needed to determine whether zinc supplementation can prevent AKI and improve outcomes in patients with CKD.
Authors
- I‐Wen Chen (ORCID: https://orcid.org/0009-0004-7122-6901)
- Ping‐Heng Tan (ORCID: https://orcid.org/0000-0001-6575-1516)
- Kuo‐Chuan Hung (ORCID: https://orcid.org/0000-0002-4507-8085)
- I‐Yin Hung
- Chun‐Ning Ho (ORCID: https://orcid.org/0000-0001-6469-226X)
- Jheng‐Yan Wu (ORCID: https://orcid.org/0000-0002-3290-1909)
- Yi‐Chen Lai (ORCID: https://orcid.org/0000-0002-6353-8102)
- Ting‐Sian Yu
- Chien‐Ming Lin (ORCID: https://orcid.org/0000-0001-7525-5743)
Institutions
- National Sun Yat-sen University (TW)
- E-Da Hospital (TW)
- Chi Mei Medical Center (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fnut.2025.1658308
- Citations
- 3
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 3.36