In vitro and ex vivo immunomodulatory effects of human placental mesenchymal stem cells in hidradenitis suppurativa
Placental MSCs, especially in their naïve form, demonstrate potent immunomodulatory effects by reducing pro-inflammatory cytokines and altering T cell dynamics in HS. Compared to adalimumab, MSCs offer a broader immunoregulatory profile, suggesting their potential as a multitarget therapy for HS. These findings support further clinical investigation of MSC-based treatments in managing this complex disease.
Authors
- Christos C. Zouboulis (ORCID: https://orcid.org/0000-0003-1646-2608)
- Ugne Janonyte (ORCID: https://orcid.org/0000-0002-3924-5406)
- Rūta Insodaitė (ORCID: https://orcid.org/0000-0003-1509-3660)
- Justinas Mačiulaitis (ORCID: https://orcid.org/0000-0002-1265-8657)
- Romaldas Mačiulaitis (ORCID: https://orcid.org/0000-0003-0106-4033)
- Vaiva Jarienė (ORCID: https://orcid.org/0000-0003-1528-1792)
- Astra Vitkauskienė (ORCID: https://orcid.org/0009-0001-6107-9731)
- Skaidra Valiukevičienė (ORCID: https://orcid.org/0000-0003-1219-5928)
- Paulius Valiukevičius (ORCID: https://orcid.org/0000-0002-6611-2334)
- Evelina Zemaite
Institutions
- Lithuanian University of Health Sciences (LT)
- Hospital of Lithuanian University of Health Sciences Kaunas Clinics (LT)
- SKiN Health (CA)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1642014
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lietuvos Mokslo Taryba