The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway
VOA significantly alleviates neuroinflammation in TS rats by modulating the activity of the p38 MAPK/NLRP3/STAT3 signaling pathway, thereby improving the pathological characteristics of TS. These findings suggest that VOA could be a potential candidate for treating TS and other neuroinflammation-related diseases.
Authors
- Yanqing Ding (ORCID: https://orcid.org/0000-0003-1775-6923)
- Guangyu Guo (ORCID: https://orcid.org/0000-0002-0880-6637)
- Peng Feng
- Nan Yang (ORCID: https://orcid.org/0000-0001-5491-8966)
- Jun Yao (ORCID: https://orcid.org/0000-0002-4916-3412)
- Zhaoyu Shi (ORCID: https://orcid.org/0000-0002-8542-523X)
- Wei Dong Xing (ORCID: https://orcid.org/0000-0003-4098-4860)
- Jing Shang (ORCID: https://orcid.org/0000-0001-6713-292X)
- Shuang Huang (ORCID: https://orcid.org/0000-0002-9674-2249)
- Fu‐Shan Xue (ORCID: https://orcid.org/0000-0002-1028-6036)
- Kexin Sun (ORCID: https://orcid.org/0009-0008-8267-8195)
- Hao Mei (ORCID: https://orcid.org/0000-0003-0242-7035)
- Bing Jiang (ORCID: https://orcid.org/0000-0001-6594-4019)
- Yuanhuan Chen
- Min Cui
- Yongyan Tian
- Yuezhen He
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Hexi University (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fphar.2025.1540092
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hexi University
- National Natural Science Foundation of China
- Gansu University of Chinese Medicine
- Science and Technology Program of Gansu Province