Efficacy of vedolizumab as maintenance therapy in a patient with ulcerative colitis on hemodialysis for end-stage renal failure: a case report
Clinical remission with complete mucosal healing (Mayo endoscopic score 0) was achieved by week 22. Post-dialysis trough serum VDZ concentration measured 13.35 μg/mL, with no detectable anti-drug antibodies. Renal function remained stable throughout (estimated glomerular filtration rate [eGFR] 3.45 mL/min/1.73m<sup>2</sup>), confirming therapeutic efficacy without exacerbation of uraemic complications.
Authors
- Zezheng Wang (ORCID: https://orcid.org/0000-0002-4065-0820)
- Jing Tang (ORCID: https://orcid.org/0000-0003-1013-147X)
- Shiying Wang (ORCID: https://orcid.org/0000-0002-1005-0381)
- Haiyan Zhang (ORCID: https://orcid.org/0009-0005-6955-564X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fmed.2025.1616425
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province
- Science and Technology Planning Project of Guangdong Province