Single-cell multi-omics dissection of c-Myb/AURKA-mediated autophagy and metabolic reprogramming in diabetic adipose-derived stem cells
Our study integrates multi-omics to demonstrate that DM induces distinct ADSCs subpopulations with dysregulated cell cycle, stemness, autophagy, apoptosis and metabolic profiles. HG activates c-Myb/AURKA-mediated autophagy in ADSCs, suggesting a potential regulatory mechanism in diabetic inflammatory microenvironments. Upregulating c-Myb may restore ADSCs function in DFUs, providing a foundation for future personalized therapies.
Authors
- Wen Liang Zha
- Yating Yin (ORCID: https://orcid.org/0000-0001-8741-5820)
- Bin Wang (ORCID: https://orcid.org/0000-0002-0161-1642)
- Wenwen Shao (ORCID: https://orcid.org/0009-0002-8888-3225)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1665909
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China