Propionic acid mediates the renoprotective effects of fecal microbiota transplantation against ischemia–reperfusion injury via upregulating GPR43
These findings provide novel insights into microbiota-targeted therapeutic strategies for kidney IRI and highlight propionic acid as a potential therapeutic agent.
Authors
- Tiejun Pan (ORCID: https://orcid.org/0000-0002-9193-7362)
- Yalong Xu (ORCID: https://orcid.org/0000-0002-9562-6158)
- Hongzhe Tian
- Lei Gao (ORCID: https://orcid.org/0000-0003-3948-9213)
- Jingxuan Yu
- Qiang Xie (ORCID: https://orcid.org/0000-0002-7003-7533)
- Yu Zhou (ORCID: https://orcid.org/0000-0002-8193-7561)
- Yan Wang (ORCID: https://orcid.org/0000-0002-1490-7450)
- Lin Wang (ORCID: https://orcid.org/0000-0002-0503-9727)
- Zhenyu Liu (ORCID: https://orcid.org/0000-0002-3525-273X)
- Tao Wang (ORCID: https://orcid.org/0000-0001-6402-5571)
- Dongliang Chen (ORCID: https://orcid.org/0000-0003-3637-9764)
- Min Wang (ORCID: https://orcid.org/0009-0003-5120-7386)
- Feng Zhao (ORCID: https://orcid.org/0000-0002-6830-767X)
- Guan Zhang (ORCID: https://orcid.org/0000-0002-5942-2481)
- Wei Liu (ORCID: https://orcid.org/0000-0003-2018-7004)
Institutions
- Wuhan University of Technology (CN)
- Institute for the Future (US)
- Central Hospital of Wuhan (CN)
- Peptide Institute (Japan) (JP)
- Wuhan General Hospital of Guangzhou (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1616164
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province