Phenotypic characterization of two neuroinvasive Toscana virus strains clinically associated with self-limited and persistent infections in human neural cells and brain organoids
Distinct host-pathogen interactions underlie the divergent clinical courses of TOSV strains. The findings provide insights into mechanisms of viral persistence in the human brain and may guide future therapeutic strategies.
Authors
- Letizia Rizzo
- Marta Trevisan (ORCID: https://orcid.org/0000-0002-3148-7240)
- Gianni Gori Savellini (ORCID: https://orcid.org/0000-0003-2287-9258)
- Emanuela Dal Molin
- Camilla Lucca (ORCID: https://orcid.org/0000-0002-4897-9620)
- Maria Grazia Cusi (ORCID: https://orcid.org/0000-0001-8869-8164)
- Giulia Alessandri
- Chiara Terrosi
- Luisa Barzon (ORCID: https://orcid.org/0000-0003-0720-8456)
- Gabriele Anichini (ORCID: https://orcid.org/0000-0001-9895-2488)
- Stefania Vogiatzis
Institutions
- University of Siena (IT)
- University of Padua (IT)
- Ospedale Santa Maria alle Scotte (IT)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1658107
- Citations
- 2
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Ministero dell'Università e della Ricerca
- National Institute of Allergy and Infectious Diseases