Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene–environment interaction study
This study identified significant gene-environment interactions between VEGFA polymorphisms (rs3025010 and rs10434) and Pb-Cd co-exposure in renal dysfunction. These findings suggest that screening for these polymorphisms could identify high-risk populations for targeted prevention and control strategies.
Authors
- Weixia Duan
- Yapei Sun
- Guoliang Li (ORCID: https://orcid.org/0000-0002-1190-9725)
- Lili Liu (ORCID: https://orcid.org/0000-0002-1237-1568)
- Zhiqiang Zhao (ORCID: https://orcid.org/0000-0003-2556-1018)
- Yingke Wen (ORCID: https://orcid.org/0000-0001-7331-9360)
- Jing Yang (ORCID: https://orcid.org/0000-0001-9838-5102)
- Le Yang
- Jiazhen Zhou (ORCID: https://orcid.org/0000-0002-8628-8273)
- Mengying Qiu
- Yaotang Deng
Institutions
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fpubh.2025.1627634
- Citations
- 1
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China