Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study
Our findings indicate that the LFT elicits more extensive prefrontal activation, with differential engagement of the VLPFC in BD compared to UD. These results suggest potential neuroimaging biomarkers for distinguishing between UD and BD, while also providing insights into the neural substrates of language processing.
Authors
- Guimei Cui (ORCID: https://orcid.org/0000-0003-4331-8521)
- Juan Li (ORCID: https://orcid.org/0000-0002-9296-9390)
- Junlin Mu
- Qi Lu (ORCID: https://orcid.org/0000-0002-8353-765X)
- Zhaohui Zhang (ORCID: https://orcid.org/0000-0002-6709-7631)
- Juan Hui (ORCID: https://orcid.org/0000-0002-1546-0953)
- Haiyue Dai (ORCID: https://orcid.org/0000-0002-8308-1584)
- Juan Wang (ORCID: https://orcid.org/0000-0003-1234-3150)
- Shina Gu
- Lin Zhao (ORCID: https://orcid.org/0000-0001-8274-3139)
Institutions
- Henan Psychiatric Hospital (CN)
- Shandong Mental Health Center (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fpsyt.2025.1610703
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Henan Province
- Xinxiang Medical University