Study on the impact of biofilm formation by Candida albicans in recurrent vulvovaginal candidiasis on drug susceptibility
Stronger biofilm-forming <i>Candida albicans</i> strains showed higher MBEC values. In RVVC, clotrimazole had the lowest MIC and MBEC, supporting its potential as a first-line treatment. Expression of <b>CDR1</b> and <b>CDR2</b> was highest in strong biofilm-forming strains, suggesting that biofilm formation promotes antifungal resistance through enhanced efflux gene expression, especially in RVVC.
Authors
- Y.-P. Peng (ORCID: https://orcid.org/0009-0008-8432-6433)
- Sainan Li (ORCID: https://orcid.org/0000-0002-1880-6294)
- Wenjin Qi
- S. Wang
- Zijia Shen
Institutions
- Kunming Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1663099
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education
- Yunnan Provincial Department of Education Science Research Fund Project