Dynamic profiles of 25 serum biomarkers in acute myocardial infarction
This study is the first to systematically characterize the dynamic profiles of 25 serum biomarkers following AMI in rats, revealing that: (1) IL-1β, S100A8, BNP, SLC31A1 and Cys may serve as an ultra-early (1 h) diagnostic panel (increase of over 70% at 1 h); (2) the delayed elevation of α-SMA and CXCL16 may be associated with the initiation of myocardial repair; (3) the suppression of Lp-α and D2D might reflect compensatory protective mechanisms.
Authors
- Hong-Li Geng (ORCID: https://orcid.org/0000-0002-3349-6810)
- Xuefeng Ai (ORCID: https://orcid.org/0000-0002-5525-7351)
- Xue Lei (ORCID: https://orcid.org/0000-0001-9647-3782)
- J. Chen (ORCID: https://orcid.org/0000-0002-1925-8189)
- Qianyu Han
- Mengdi Jiang
- Cheng Wang (ORCID: https://orcid.org/0000-0002-7784-0169)
- Yuxiang Jin
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-1367-0989)
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcvm.2025.1631648
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00