Impact of hypercoagulable state on Crohn’s disease severity and progression: transcriptomic and single-cell analyses of the ileum
Our findings nominate CCR6<sup>+</sup>OLFM4<sup>+</sup> stem cells as cellular mediators of coagulation-associated CD progression, suggesting the CCR6-PI3K-Akt axis as a potential therapeutic target requiring validation in larger cohorts.
Authors
- Fangting Wu (ORCID: https://orcid.org/0009-0009-2789-9216)
- Fengfei Wu (ORCID: https://orcid.org/0000-0001-6807-4733)
- Fang Xie
- Sinan Zhang (ORCID: https://orcid.org/0000-0002-3894-5080)
- Ming‐Chao Huang (ORCID: https://orcid.org/0000-0001-7571-1729)
- Lihua Zhou (ORCID: https://orcid.org/0000-0002-3682-7929)
- Yongfeng Yang (ORCID: https://orcid.org/0009-0001-9266-0916)
- Lan Bai (ORCID: https://orcid.org/0000-0001-9749-0867)
- Side Liu (ORCID: https://orcid.org/0000-0001-8575-1468)
- Wenting Xie
Institutions
- Guilin Medical University (CN)
- Dongguan People’s Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1611114
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation