IFITM1 Influences Natural Killer Cell-Mediated Cytotoxicity by Modulation of HLA class I Expression in Triple-Negative Breast Cancer Cells
IFITM1 overexpression was associated with Wnt/β-catenin signaling and NK cell-mediated cytotoxicity via downregulation of HLA class I in TNBC cells, suggesting that IFITM1 might have immunoregulatory effects on the tumor microenvironment.
Authors
- Changjoo Park (ORCID: https://orcid.org/0009-0008-1847-2387)
- Soon Auck Hong (ORCID: https://orcid.org/0000-0002-7902-4608)
- Gye-Chun Cho (ORCID: https://orcid.org/0000-0001-8582-9237)
- Keunsoo Kang (ORCID: https://orcid.org/0000-0003-0611-9320)
- Young‐Ho Ahn (ORCID: https://orcid.org/0000-0002-8301-5886)
- Inyoung Cheon
- Yoon Ho Ko (ORCID: https://orcid.org/0000-0002-2506-3740)
- Hye Sung Won (ORCID: https://orcid.org/0000-0002-5134-4538)
- Heejin Lee (ORCID: https://orcid.org/0000-0003-3403-683X)
- Jung‐Sook Yoon
Institutions
- Ewha Womans University (KR)
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- Chung-Ang University (KR)
- Catholic University of Korea (KR)
- Dankook University (KR)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-09-25
- DOI
- https://doi.org/10.4143/crt.2025.444
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Catholic University of Korea
- National Research Foundation of Korea