Factor XI Deficiency in apoE/FXI Double-Knockout Mice Decreases Atherosclerosis by Lowering <i>MSR1</i> mRNA Expression Within the Plaque
Downregulated expression of <i>MSR1</i> within the atherosclerotic plaques of apoE/FXI DKO mice compared to apoE KO mice was associated with significantly reduced atherosclerosis. Targeting FXI may therefore represent a promising anti-atherogenic therapeutic strategy in addition to its known antithrombotic effects.
Authors
- Rosanna Asselta (ORCID: https://orcid.org/0000-0001-5351-0619)
- Reut Shnerb Ganor (ORCID: https://orcid.org/0000-0003-0263-6443)
- Ilia Tamarin (ORCID: https://orcid.org/0000-0001-9076-3439)
- Michal Kandel Kfir
- Gil S. Leichner
- Stefano Duga (ORCID: https://orcid.org/0000-0003-3457-1410)
- Ginette Schiby
- Ophira Salomon (ORCID: https://orcid.org/0000-0001-6068-0675)
- Aviv Shaish (ORCID: https://orcid.org/0000-0003-0203-9569)
- Dror Harats (ORCID: https://orcid.org/0009-0009-6456-6752)
- Elvezia Maria Paraboschi (ORCID: https://orcid.org/0000-0002-7935-798X)
- David M. Steinberg (ORCID: https://orcid.org/0000-0001-9112-1809)
- Mika Anekstein Spigel
Institutions
- Humanitas University (IT)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- IRCCS Humanitas Research Hospital (IT)
- Achva Academic College (IL)
Publication Details
- Journal
- Journal of Lipid and Atherosclerosis
- Published
- 2025-01-01
- DOI
- https://doi.org/10.12997/jla.2025.14.3.372
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00