A Multicenter Randomized Controlled Trial of Antimicrobial Prophylaxis to Prevent Urinary Tract Infections after Shockwave Lithotripsy for Urolithiasis: The APPEAL Trial
A single dose of ciprofloxacin reduced the risk of post-SWL pyelonephritis, with a modest absolute benefit. The patient importance of this reduction depends on individual preferences in weighing a small absolute reduction in risk against the potential harms and resistance-related implications of antibiotic use. Results from the APPEAL trial will inform global practice and support evidence-based decision-making for patients undergoing SWL.
Authors
- Negar Pourjamal (ORCID: https://orcid.org/0000-0002-1430-3075)
- Agus Rizal Ardy Hariandy Hamid (ORCID: https://orcid.org/0000-0002-7538-2811)
- Murilo Luz (ORCID: https://orcid.org/0000-0002-0575-5635)
- Sakineh Hajebrahimi (ORCID: https://orcid.org/0000-0003-1494-7097)
- Raed A. Azhar
- Alireza Farshi (ORCID: https://orcid.org/0000-0003-1456-6155)
- Pauliina Kuutti
- Mohamed Abdelkareem (ORCID: https://orcid.org/0000-0001-6639-2762)
- Tuomas P. Kilpeläinen (ORCID: https://orcid.org/0000-0002-7697-0148)
- Saana Horstia
- Borna Tadayon Najafabadi (ORCID: https://orcid.org/0000-0003-1249-0660)
- John D. Denstedt (ORCID: https://orcid.org/0000-0001-5836-4200)
- Arto Mikkola
- Kathrin Bausch (ORCID: https://orcid.org/0000-0002-6253-0854)
- Samuel Lagabrielle (ORCID: https://orcid.org/0000-0002-1905-5808)
- Sanna Myrskysalo
- Alex L E Halme (ORCID: https://orcid.org/0000-0001-6597-818X)
- Farzin Soleimanzadeh (ORCID: https://orcid.org/0000-0003-2427-8819)
- Kari A.O. Tikkinen (ORCID: https://orcid.org/0000-0002-1389-8214)
- D. S. Gorelov (ORCID: https://orcid.org/0000-0002-7592-8167)
- Mari Saalasti
- Pramila Gaudel (ORCID: https://orcid.org/0000-0002-8919-0239)
- Saqib Hussain
- Jani Ruotsalainen (ORCID: https://orcid.org/0009-0004-4028-5220)
- Andrey Morozov (ORCID: https://orcid.org/0000-0001-6694-837X)
- Patrick O. Richard (ORCID: https://orcid.org/0000-0002-8904-8873)
- Sara Tornberg (ORCID: https://orcid.org/0000-0002-9666-2126)
- Thomas O. Tailly (ORCID: https://orcid.org/0000-0001-5801-5801)
- Hanieh Salehi‐Pourmehr (ORCID: https://orcid.org/0000-0001-9030-2106)
- Nariman K. Gadzhiev (ORCID: https://orcid.org/0000-0002-6255-0193)
- Petrus Järvinen (ORCID: https://orcid.org/0000-0002-3751-4609)
- Mohsen Mohammadrahimi (ORCID: https://orcid.org/0000-0002-2758-5788)
- Le Mai Tu
- Hassan Razvi (ORCID: https://orcid.org/0000-0002-6462-1119)
- Stephen E. Pautler (ORCID: https://orcid.org/0000-0001-9281-8122)
- Niko K Nordlund (ORCID: https://orcid.org/0009-0007-6681-9675)
- Farhad Tondroanamag
Institutions
- Western University (CA)
- University of Helsinki (FI)
- Université de Sherbrooke (CA)
- Tabriz University of Medical Sciences (IR)
- St Petersburg University (RU)
- Sechenov University (RU)
- King Abdulaziz University (SA)
- First Pavlov State Medical University of St. Petersburg (RU)
- Helsinki University Hospital (FI)
- Ghent University Hospital (BE)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- University Hospital of Basel (CH)
- University of Indonesia (ID)
- D’Or Institute for Research and Education (BR)
- Hamad General Hospital (QA)
- City Hospital No. 40 (RU)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Hamad Medical Corporation (QA)
- McMaster University (CA)
Publication Details
- Journal
- European Urology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.eururo.2025.08.019
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52