Synergistic effects of 5-azacitidine and photodynamic therapy using spirulina platensis on cell death in CAL27 oral squamous cell carcinoma Cells
Spirulina-based PDT enhances the antitumor efficacy of 5-aza in OSCC by inducing synergistic cytotoxic, apoptotic, and anti-invasive effects. These findings support the therapeutic potential of combining epigenetic and oxidative stress-based modalities in OSCC management.
Authors
- Payman Shahabi
- Mahshid Hodjat (ORCID: https://orcid.org/0000-0001-8335-3546)
- Alireza Ranjbar Hassani (ORCID: https://orcid.org/0000-0002-6422-6629)
- Hadiseh Mohammadpour
- Sogol Saberi (ORCID: https://orcid.org/0000-0003-1816-8576)
- Mojgan Alaeddini (ORCID: https://orcid.org/0000-0002-3634-7992)
Institutions
- Aja University of Medical Sciences (IR)
- Laser Research Institute (CN)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.105232
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81