Bio-hybrid scaffolds combining polyvinyl alcohol and decellularized articular cartilage for the treatment of focal chondral lesions in hemophilic patients
The findings underscore the potential of PVA/AC bio-hybrid scaffolds for cartilage regeneration in hemophilic patients affected by HA. These scaffolds combine mechanical integrity with enhanced cytocompatibility, representing a novel strategy in the context of tissue-engineered therapies for joint repair.
Authors
- Andrea Porzionato (ORCID: https://orcid.org/0000-0003-3025-4717)
- Silvia Todros (ORCID: https://orcid.org/0000-0002-6077-9672)
- Raffaele De (ORCID: https://orcid.org/0000-0002-2307-0277)
- Martina Contran (ORCID: https://orcid.org/0000-0002-3709-8414)
- Veronica Macchi (ORCID: https://orcid.org/0000-0003-2335-6897)
- Silvia Barbon
- Marta Confalonieri (ORCID: https://orcid.org/0000-0002-9322-8711)
- Pier Paolo Parnigotto (ORCID: https://orcid.org/0000-0002-1956-2041)
- Elena Stocco (ORCID: https://orcid.org/0000-0003-4572-622X)
- Alice D’Osualdo (ORCID: https://orcid.org/0009-0005-0243-3568)
- Piero G. Pavan (ORCID: https://orcid.org/0000-0002-3875-9640)
Institutions
- University of Padua (IT)
- Foundation for Cardiovascular Biomedical Research and Gene and Cell Therapy (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fphar.2025.1650467
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova