DACN-Based Switchable Fluorescent Click Reaction
The copper-free switchable fluorescent click reaction using 4,8-diazacyclononyne (DACN) and 3-azido-7-alkoxycoumarin was realized and applied to the conjugation of biomolecules. This new method using DACN has characteristics superior to those of the corresponding azadibenzocyclooctyne (DBCO) derivative in terms of fluorescence quantum yield and photostability under UV light irradiation.
Authors
- Fumi Nagatsugi (ORCID: https://orcid.org/0000-0002-5526-6020)
- Kazumitsu Onizuka (ORCID: https://orcid.org/0000-0001-9713-4619)
- Katsuhiko Tomooka (ORCID: https://orcid.org/0000-0002-0762-5746)
- Yuuya Kawasaki (ORCID: https://orcid.org/0000-0003-3354-1690)
- Kazunobu Igawa (ORCID: https://orcid.org/0000-0002-7354-5162)
- Tomoya Hayashibara
Institutions
- Kyushu University (JP)
- Tohoku University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1021/acs.joc.5c00232
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00