SYNTHESIS AND PREDICTION OF BIOLOGICAL ACTIVITY OF TRIAZOLE DERIVATIVES OF LUPINE

Preliminary screening using software methods allows you to identify the most promising chemical compounds and thereby sig nificantly save expended resources. The production of potentially biologically active compounds based on the alkaloid lupinine was carried out using the addition of substituted 1,2,3-triazole. The attractiveness of 1,2,3-triazoles is due to the versatility of their reactivity, as well as the practical use of 1,2,3-triazole derivatives as drugs in the pharmaceutical industry. Using the open platform PASSonline, the pharmacological activity of synthesized lupinine compounds was predicted. Based on the results of virtual screening, promising types of lupinine alkaloid derivatives were identified, which are potential sources of original drugs.