Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure
HF leads to IRP1/2 inactivation, ID, and metabolic dysfunction in skeletal muscle in mice. IRP1/2 inactivation in skeletal muscle causes ID, impairs oxidative energy production, and promotes exercise intolerance by reducing the capacity for effective energy utilization.
Authors
- Wenke Jonas (ORCID: https://orcid.org/0000-0002-3441-9200)
- James T. Thackeray (ORCID: https://orcid.org/0000-0002-9031-100X)
- Andreas Pich (ORCID: https://orcid.org/0000-0001-8444-0940)
- Malgorzata Szaroszyk (ORCID: https://orcid.org/0009-0008-4051-3958)
- Johann Bauersachs (ORCID: https://orcid.org/0000-0002-9341-117X)
- Frank M. Bengel (ORCID: https://orcid.org/0000-0003-4529-7963)
- Zulaikha Malik
- Magdolna Lévay
- Mario Ost (ORCID: https://orcid.org/0000-0002-1811-2049)
- Joerg Heineke (ORCID: https://orcid.org/0000-0002-1541-3030)
- Annette Schürmann (ORCID: https://orcid.org/0000-0002-4113-4377)
- Tibor Kempf (ORCID: https://orcid.org/0000-0001-6901-8442)
- Steven Nowak
- Thomas Wieland (ORCID: https://orcid.org/0000-0001-8262-8261)
- Jan Hegermann (ORCID: https://orcid.org/0000-0001-7893-8507)
- Kai C. Wollert (ORCID: https://orcid.org/0000-0002-4890-4450)
- Fatemeh Rostami (ORCID: https://orcid.org/0000-0002-0992-6227)
- Bomee Chung
Institutions
- University of Potsdam (DE)
- Heidelberg University (DE)
- Biochemical Society (GB)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- Klinikum Braunschweig (DE)
- German Centre for Cardiovascular Research (DE)
- University Medical Centre Mannheim (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- University College London (GB)
- Leipzig University (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1093/cvr/cvaf173
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00