BIOLOGICALLY ACTIVE SUBSTANCES OF “ HIPPOPHAE -5” LOZENGES

In Tibetan medicine, the multicomponent preparation “ Hippophae -5” is used for respiratory diseases. It consists of Hippophae rhamnoides L.) (fruits), Piper longum L. (fruits), Glycyrrhiza uralensis Fisch. ((roots), Phlojodicarpus sibiricus (Stephan ex Spreng) Koso-Pol. Tausch (roots), Malus sylvestris Mill. (fruits). According to scientific and traditional medicine, the biologically active substances of these plants have a pronounced anti-inflammatory, antioxidant, antibacterial and immunomodulatory effect, which indicates the advisability of using this composition as a means for treating inflammatory diseases of the respiratory organs. Lozenges were chosen as a dosage form, the excipients and special technology of which contribute to a long-term therapeutic effect of the active components. It was established that the dominant compounds of the “ Hippophae -5” lozenges, consisting of isomalt and dry extract are glycyrrhizic acid, the content of which was 27.4 mg/g; the share of coumarins (visnadine) is 7.65 mg/g, the share of piperine is 2.23 mg/g, and the share of catechin is 0.52 mg/g.