Stage Migration on Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Comparison to Conventional Imaging in Patients with High-risk Prostate Cancer Referred for Radiation Therapy: Results from the Phase 2/3 THUNDER
One-third of patients with high-risk prostate cancer referred for curative-intent radiotherapy were upstaged on PSMA PET/CT. This finding supports the use of PSMA PET/CT for staging, especially in patients with multiple high-risk features, and suggests a need for treatment adaptations accordingly, which will be further investigated in the THUNDER trial.
Authors
- Maréva Lamande
- Guillaume Grisay (ORCID: https://orcid.org/0000-0002-2784-8576)
- Nicolas Jullian (ORCID: https://orcid.org/0000-0003-3567-0285)
- Filip Poelaert (ORCID: https://orcid.org/0000-0002-2213-6211)
- Michiel Strijbos (ORCID: https://orcid.org/0000-0003-2390-3029)
- Karolien Goffin (ORCID: https://orcid.org/0000-0002-7453-0229)
- Nadia Withofs (ORCID: https://orcid.org/0000-0002-0233-4675)
- Samuel Bral
- Valérie Fonteyne (ORCID: https://orcid.org/0000-0001-6724-1595)
- Fleur Kleiburg (ORCID: https://orcid.org/0000-0003-4757-8777)
- Piet R. Dirix (ORCID: https://orcid.org/0000-0002-1278-1903)
- Sabine Meersschout
- Jolien Verschueren (ORCID: https://orcid.org/0000-0002-2432-8997)
- Brieuc Sautois (ORCID: https://orcid.org/0000-0002-0029-7735)
- Nick Liefhooghe
- Piet Ost (ORCID: https://orcid.org/0000-0002-2203-4848)
- Bart De Troyer
- Ad Vandermeulen (ORCID: https://orcid.org/0000-0001-5058-6992)
- Lorenzo Staelens
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Leiden University Medical Center (NL)
- Universitair Ziekenhuis Leuven (BE)
- AZ Groeninge (BE)
- Ghent University Hospital (BE)
- Institut Jules Bordet (BE)
- Antwerp Management School (BE)
- Onze Lieve Vrouwziekenhuis Hospital (BE)
- Province of Antwerp (BE)
- AZ Sint-Jan (BE)
- Vlaamse Vereniging voor Obstetrie en Gynaecolo (BE)
- Centre Hospitalier Universitaire de Liège (BE)
- Iridium Kankernetwerk (BE)
- AZ Delta (BE)
- Flanders Environment Agency (BE)
Publication Details
- Journal
- European Urology Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.euo.2025.08.005
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00