Macrophage MRC2 deficiency mitigates HFD-induced MASLD by downregulating CD147-regulated TNF-α production
This study identifies the critical role of MRC2 in the development of high-fat diet-induced metabolic dysfunction-associated steatotic liver disease, providing a mechanistic understanding of its involvement in macrophage-mediated inflammation. <i>M</i> <i>rc</i> <i>2</i> deficiency alleviates hepatic inflammation and lipid accumulation by downregulating CD147-regulated TNF-α production in macrophages. The findings are particularly significant for researchers and clinicians focused on liver diseases, as they reveal a novel target - the macrophage MRC2-CD147 complex - for potential therapeutic intervention.
Authors
- Yu‐Fen Chung
- Hung‐Yi Chiou (ORCID: https://orcid.org/0000-0002-4545-9697)
- Chih‐Wen Wang (ORCID: https://orcid.org/0000-0002-4720-599X)
- Hui-Ru Kuo
- Kwei-Yan Liu
- Liting Wang (ORCID: https://orcid.org/0000-0001-6146-2549)
- Ming-Hong Lin (ORCID: https://orcid.org/0000-0001-8937-0769)
- Shau-Ku Huang
Institutions
- National Taiwan Normal University (TW)
- Johns Hopkins University (US)
- Kaohsiung Medical University (TW)
- National Health Research Institutes (TW)
- National Chi Nan University (TW)
- Johns Hopkins Medicine (US)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kaohsiung Municipal Hsiao-Kang Hospital (TW)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101601
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00