Spatial distribution of Intra-retinal Hyper-reflective foci and impact on progression in eyes with intermediate Age-related macular degeneration
IHRF do not distribute evenly across the macula in eyes with iAMD, with a higher density centrally, but greater frequency parafoveally. IHRF tend to distribute more peripherally over time, however, among eyes that progress to late AMD. These observations may provide new insights into the pathophysiology of these lesions.
Authors
- Srinivas R. Sadda (ORCID: https://orcid.org/0000-0002-4939-3306)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Margaret Ann Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Dwight Stambolian
- Muneeswar Gupta Nittala (ORCID: https://orcid.org/0000-0002-3802-6594)
- Aditya Verma (ORCID: https://orcid.org/0000-0003-3778-8834)
Institutions
- University of Louisville (US)
- University of Miami (US)
- University of California, Los Angeles (US)
- Doheny Eye Institute (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s00417-025-06964-w
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Eye Institute