Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy
A multiplex apolipoprotein panel led to better prediction of MACE and all-cause death, beyond lipids, in patients with postacute coronary syndrome on optimized statin therapy. The panel also predicts the treatment benefit of alirocumab. Further validation of this approach is now needed, and if confirmed and improved, it could lead to better disease prediction and management in the future.
Authors
- Philippe Gabríel Steg (ORCID: https://orcid.org/0000-0001-6896-2941)
- J. Wouter Jukema (ORCID: https://orcid.org/0000-0002-3246-8359)
- Deepak L. Bhatt (ORCID: https://orcid.org/0000-0002-1278-6245)
- Christa M. Cobbaert (ORCID: https://orcid.org/0000-0003-3565-1404)
- Fred P.H.T.M. Romijn (ORCID: https://orcid.org/0000-0003-4470-7959)
- Shaun G. Goodman (ORCID: https://orcid.org/0000-0001-8068-2440)
- Vera Bittner (ORCID: https://orcid.org/0000-0001-9456-850X)
- Esther Reijnders (ORCID: https://orcid.org/0000-0003-3520-5869)
- Robert A. Harrington (ORCID: https://orcid.org/0000-0001-5450-8676)
- Patrick M. Bossuyt (ORCID: https://orcid.org/0000-0003-4427-0128)
- Rafael Dı́az (ORCID: https://orcid.org/0000-0002-8637-5967)
- Harvey D. White (ORCID: https://orcid.org/0000-0001-7712-6750)
- Gregory G. Schwartz (ORCID: https://orcid.org/0000-0003-2954-0695)
- Michael Szarek (ORCID: https://orcid.org/0000-0002-0046-0264)
- L. Renee Ruhaak (ORCID: https://orcid.org/0000-0003-3737-3807)
- Stella Trompet (ORCID: https://orcid.org/0000-0001-5006-0528)
- Sergio Fazio (ORCID: https://orcid.org/0000-0002-8145-8034)
- Irena Stevanovic (ORCID: https://orcid.org/0000-0002-0516-1909)
Institutions
- St. Michael's Hospital (CA)
- Inserm (FR)
- SUNY Downstate Health Sciences University (US)
- Regeneron (United States) (US)
- Université Paris Cité (FR)
- Cornell University (US)
- Leiden University Medical Center (NL)
- The Medical Center of Aurora (US)
- Sanofi (France) (FR)
- University of Alabama at Birmingham (US)
- Greenlane Clinical Centre (NZ)
- Assistance Publique – Hôpitaux de Paris (FR)
- Mount Sinai Hospital (US)
- Netherlands Heart Institute (NL)
- Canadian VIGOUR Centre (CA)
- Estudios Clínicos Latinoamérica (AR)
- Hôpital Bichat-Claude-Bernard (FR)
- Instituto Cardiovascular de Rosario (AR)
- GGD Amsterdam (NL)
- University of Colorado Denver (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1161/atvbaha.124.322336
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 4.01