Cumulative weight–based rabbit antithymocyte globulin dosing for induction in heart transplantation: Impact on outcomes
At 24 months post-HTx, our findings suggest that a cumulative rATG dosing of 4.5 to 7.5 mg/kg offers the best balance of AR, mortality, and infection, mainly by reducing the risk of infections and to a lesser degree mortality, without increasing AR. A cumulative dose of <4.5 mg/kg offers the lowest risk of infection, with 4.5 mg/kg likely representing the intersection dose.
Authors
- Yoan Lamarche (ORCID: https://orcid.org/0000-0002-3277-0419)
- Maxime Tremblay‐Gravel (ORCID: https://orcid.org/0000-0001-6586-2064)
- Anique Ducharme
- Geneviève Giraldeau
- Simon de Denus (ORCID: https://orcid.org/0000-0001-5404-7929)
- Emmanuel Bebawi (ORCID: https://orcid.org/0000-0002-6968-8371)
- Annik Fortier
- Marie‐Claude Parent (ORCID: https://orcid.org/0000-0001-7886-8115)
- Jacinthe Boulet (ORCID: https://orcid.org/0000-0003-1782-9213)
- P. Noly
- Winston H. Tran
Institutions
- Montreal Heart Institute (CA)
- The Coordinating Center (US)
- Université de Montréal (CA)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100391
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00