Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children
This study underscores the alarming prevalence of MDR and XDR <i>S. typhi</i> isolates among pediatric patients, driven by resistance genes such as <i>bla</i>_CTX-M-15, <i>bla</i>_TEM-1B, and <i>gyrA</i>-S83F. These findings highlight the urgent need for targeted therapeutic strategies and robust surveillance systems to combat the growing threat of drug-resistant typhoid fever.
Authors
- Shabir Ahmad (ORCID: https://orcid.org/0000-0002-6782-8713)
- Otávio Cabral-Marques (ORCID: https://orcid.org/0000-0002-3183-6236)
- Azra
- Ganwu Li (ORCID: https://orcid.org/0000-0002-6370-9573)
- Ihtisham Ul Haq (ORCID: https://orcid.org/0000-0002-0806-6907)
- Aiman Waheed (ORCID: https://orcid.org/0009-0006-6272-2705)
- Susana Campino (ORCID: https://orcid.org/0000-0003-1403-6138)
- Muhammad Riaz (ORCID: https://orcid.org/0000-0002-7599-6928)
- Zia Ud Din (ORCID: https://orcid.org/0000-0002-1491-7149)
- Taane Gregory Clark (ORCID: https://orcid.org/0000-0001-8985-9265)
- Jody Phelan (ORCID: https://orcid.org/0000-0001-8323-7019)
- Gulab Fatima Rani (ORCID: https://orcid.org/0000-0002-2209-1893)
- Sajjad Ahmad (ORCID: https://orcid.org/0000-0002-8336-4314)
- Fazal Sattar (ORCID: https://orcid.org/0000-0003-1122-9727)
- Sajid Ali (ORCID: https://orcid.org/0000-0002-3654-6529)
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of London (GB)
- National Institute for Biotechnology and Genetic Engineering (PK)
- Pakistan Institute of Engineering and Applied Sciences (PK)
- Iowa State University (US)
- Kohat University of Science and Technology (PK)
- Universidade de São Paulo (BR)
- Sarhad University of Science and Information Technology (PK)
- Khyber Medical University (PK)
- University of Peshawar (PK)
- London School of Hygiene & Tropical Medicine (GB)
- D’Or Institute for Research and Education (BR)
Publication Details
- Journal
- Pathogens
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3390/pathogens14100967
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00