Multifunctional Bioactive Coatings Based on Bioglass, Vitamin D3, and Melittin Deposited via MAPLE for Enhanced Osseointegration, Antibacterial Activity, and Corrosion Resistance of Titanium Implants

Abstract This study presents the development of multifunctional bioactive coatings composed of bioglass, vitamin D3, and melittin, deposited on titanium substrates using the Matrix‐Assisted Pulsed Laser Evaporation technique. The goal is to enhance the biological and physicochemical performance of titanium implants through improved osseointegration, corrosion resistance, and antibacterial activity. Comprehensive characterization reveals that the composite coatings exhibited excellent chemical integrity and favorable micro/nanostructured morphology, promoting cellular adhesion and viability. Electrochemical analyses demonstrate that the bioglass, vitamin D3, and melittin composite coating significantly improves the corrosion resistance of titanium in simulated body fluid, indicating long‐term material stability. Biological assays confirm the coatings’ biocompatibility and their ability to support osteogenic differentiation without inducing cytotoxic or immunotoxic effects. Moreover, the laser obtained coatings show a sustained release of active compounds over 7 weeks and robust antibiofilm activity against pathogens such as S. aureus , P. aeruginosa , and E. coli . These results highlight the synergistic potential of bioglass, vitamin D3, and melittin in addressing critical challenges in implantology, positioning these coatings as a promising strategy for next‐generation biomedical implants with enhanced functionality and longevity.