A Systematic Review of Submandibular Gland Primary Squamous Cell Carcinoma: Clinical Characteristics, Treatment Paradigms, and Survival Outcomes

PSCC of the SMG is an aggressive malignancy requiring multimodal management. Surgical resection with adjuvant radiotherapy/chemotherapy is common, yet high recurrence rates and metastatic risk persist. Diagnostic rigor remains critical to exclude mimics and metastases. Future studies should establish standardized protocols integrating molecular targeting (eg, EGFR/Wnt pathways).