Jejupeptins A and B, Polyketide–Cyclic Peptide Hybrids with Anti-Corticosterone Activity from <i>Streptomyces</i> sp. KCB15JA151
Two new lipopeptides jejupeptins A (<b>1</b>) and B (<b>2</b>), together with a known compound eurystatin B (<b>3</b>), were isolated from a culture of <i>Streptomyces</i> sp. KCB15JA151. The chemical structures of the compounds were elucidated by using a combination of 1D and 2D NMR spectroscopy analyses. Comprehensive spectroscopic analysis revealed that compounds <b>1</b> and <b>2</b> possess a 1-aminoethyl-2-hydroxy-4-oxopentanoic acid moiety. A plausible biosynthetic pathway for these compounds was proposed. Biological evaluation demonstrated that compounds <b>1</b> and <b>2</b> exhibit protective effects against corticosterone-induced apoptosis and cellular oxidative stress without any associated cytotoxicity.
Authors
- Hyeok‐Won Lee
- Sung‐Kyun Ko (ORCID: https://orcid.org/0000-0002-8202-1205)
- Shunji Takahashi (ORCID: https://orcid.org/0000-0003-1684-9298)
- Gil Soo Kim
- Jihun Park
- Jun‐Pil Jang
- Jae‐Hyuk Jang (ORCID: https://orcid.org/0000-0002-4363-4252)
- Young‐Soo Hong (ORCID: https://orcid.org/0000-0001-7768-2239)
- Jongtae Roh (ORCID: https://orcid.org/0000-0003-1114-8580)
- Beomcheol Park
- Gwi Ja Hwang
Institutions
- University of Science and Technology (YE)
- Biotechnology Research Center (IR)
- RIKEN Center for Sustainable Resource Science (JP)
- Central Research Institute (IN)
- Hanpoong Pharm (South Korea) (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1021/acsomega.5c03784
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39