Circulating microRNAs associated with tumour necrosis factor or fibloblast-like synoviocyte predict cartilage damage in early rheumatoid arthritis treated with methotrexate plus adalimumab: a subanalysis of the MIRACLE study
Higher circulating miRNA levels predicted subsequent cartilage damage in early RA treated with a TNF inhibitor in addition to MTX. Thus, the MTX dose at ADA initiation should not be reduced in patients with high microRNA levels.
Authors
- Keisuke Izumi (ORCID: https://orcid.org/0000-0001-8597-0759)
- Yasunori Sato (ORCID: https://orcid.org/0000-0002-7189-5126)
- Kichul Shin (ORCID: https://orcid.org/0000-0002-6749-7598)
- H. Tamai (ORCID: https://orcid.org/0000-0001-8784-2224)
- Chang‐Fu Kuo (ORCID: https://orcid.org/0000-0002-9770-5730)
- Yuko Kaneko (ORCID: https://orcid.org/0000-0003-2646-5765)
- Hidekata Yasuoka (ORCID: https://orcid.org/0000-0002-2405-6282)
- Tomonori Ishii (ORCID: https://orcid.org/0000-0001-5361-5824)
- Wen‐Chan Tsai
- Hiroaki Taguchi (ORCID: https://orcid.org/0000-0003-3183-6380)
- Hideto Kameda (ORCID: https://orcid.org/0000-0002-4330-5782)
- Toshihisa Kojima (ORCID: https://orcid.org/0000-0001-8497-0212)
- Kei Ikeda (ORCID: https://orcid.org/0000-0003-0574-9611)
- Masataka Kuwana (ORCID: https://orcid.org/0000-0001-8352-6136)
- Yasushi Kondo (ORCID: https://orcid.org/0000-0002-1566-2088)
- Tsutomu Takeuchi (ORCID: https://orcid.org/0000-0003-1111-8218)
- Yusuke Yoshida (ORCID: https://orcid.org/0000-0002-0774-0509)
- Toshiaki Miyamoto (ORCID: https://orcid.org/0000-0002-1944-4280)
- Shintaro Hirata (ORCID: https://orcid.org/0000-0002-2474-9943)
- Masahiko Mori (ORCID: https://orcid.org/0000-0003-3673-384X)
- Yohei Hosokawa
Institutions
- Fujita Health University (JP)
- Keio University (JP)
- Chang Gung Memorial Hospital (TW)
- Hiroshima University Hospital (JP)
- Eisai (Japan) (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.55563/clinexprheumatol/keymab
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.67