Evaluation of Platelet-rich Fibrin Matrix Dressings in Patients with Chronic Nonhealing Leg Ulcers

Background: Chronic nonhealing ulcers of the lower extremity are a cause of morbidity and mortality. Platelets are cells that play a central role in wound healing, and they are the main source of the growth factor complex that plays the main role in natural wound healing. Purpose: To assess the safety and efficacy of the autologous platelet-rich fibrin matrix (PRFM) as wound dressing in the treatment of chronic nonhealing leg ulcers. Methods: This prospective study included 17 patients with chronic nonhealing leg ulcers >6-week duration, which failed conventional treatment. PRFM dressings were applied at weekly intervals till a maximum of 8 weeks. Results: The mean number of sittings required for complete healing of the ulcer was 5. The mean number of sittings required for complete healing of the ulcer in leprosy patients’ group was 4, venous ulcer group was 5.4, diabetic ulcer group was 7, traumatic ulcer group was 5, and vasculitic ulcer group was 5. Conclusion: PRFM dressings are a simple, safe, and feasible method for the treatment of nonhealing leg ulcers.