Microbial Metabolic Pathways Guide Response to Immune Checkpoint Blockade Therapy

Microbial metabolic pathways are highly conserved across individuals and therefore offer an opportunity to link the microbiome to immunotherapy efficacy. We identified specific microbial metabolic pathways associated with response to ICB and provided mechanistic insights into the immunomodulatory influence of these pathways on antitumor immunity.

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Publication Details

Journal
Cancer Discovery
Published
2025-09-25
DOI
https://doi.org/10.1158/2159-8290.cd-24-1669
Citations
1
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.80
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Microbial Metabolic Pathways Guide Response to Immune Checkpoint Blockade Therapy

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Microbial Metabolic Pathways Guide Response to Immune Checkpoint Blockade Therapy

Michaël Noë, Mathilde Martinez, Krijn K. Dijkstra, Laurien J. Zeverijn, Iris Mimpen, Edwin C.A. Stigter, Lodewyk F.A. Wessels, Hans A. J. Gelderblom, Thomas Battaglia, Annegien Broeks, Boudewijn Burgering, Marcel R. de Zoete, Vincent van der Noort, Birgit S. Geurts, Karlijn Verkerk, Merel van Gogh, Allard W. J. van Renterghem, Catherine Toner-Bartelds, Can Gulersonmez, Louisa R. Hoes, Emile E. Voest, Ingrid Hofland
article en
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Abstract

Microbial metabolic pathways are highly conserved across individuals and therefore offer an opportunity to link the microbiome to immunotherapy efficacy. We identified specific microbial metabolic pathways associated with response to ICB and provided mechanistic insights into the immunomodulatory influence of these pathways on antitumor immunity.

Cancer DiscoveryVol. 16(1)
Dutch Cancer Society (NL), Leiden University Medical Center (NL), The Netherlands Cancer Institute (NL), University Medical Center Utrecht (NL), Oncode Institute (NL), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL), Cancer Genomics Centre (NL), Delft University of Technology (NL)
Openalex Percentile: Top 23%
Immune cells in cancer
0.80
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