Microbial Metabolic Pathways Guide Response to Immune Checkpoint Blockade Therapy
Microbial metabolic pathways are highly conserved across individuals and therefore offer an opportunity to link the microbiome to immunotherapy efficacy. We identified specific microbial metabolic pathways associated with response to ICB and provided mechanistic insights into the immunomodulatory influence of these pathways on antitumor immunity.
Authors
- Michaël Noë (ORCID: https://orcid.org/0000-0002-5336-4508)
- Mathilde Martinez
- Krijn K. Dijkstra (ORCID: https://orcid.org/0000-0002-5417-5397)
- Laurien J. Zeverijn (ORCID: https://orcid.org/0009-0001-1124-7987)
- Iris Mimpen (ORCID: https://orcid.org/0000-0001-6177-8607)
- Edwin C.A. Stigter (ORCID: https://orcid.org/0000-0001-5970-4668)
- Lodewyk F.A. Wessels (ORCID: https://orcid.org/0000-0002-1656-6995)
- Hans A. J. Gelderblom (ORCID: https://orcid.org/0000-0001-9270-8636)
- Thomas Battaglia (ORCID: https://orcid.org/0000-0002-5520-0478)
- Annegien Broeks (ORCID: https://orcid.org/0000-0002-8699-5058)
- Boudewijn Burgering (ORCID: https://orcid.org/0000-0002-4044-9596)
- Marcel R. de Zoete (ORCID: https://orcid.org/0000-0002-6561-5810)
- Vincent van der Noort (ORCID: https://orcid.org/0000-0002-4910-4535)
- Birgit S. Geurts (ORCID: https://orcid.org/0009-0007-7205-0890)
- Karlijn Verkerk (ORCID: https://orcid.org/0000-0002-5882-4980)
- Merel van Gogh (ORCID: https://orcid.org/0000-0002-5826-5066)
- Allard W. J. van Renterghem
- Catherine Toner-Bartelds
- Can Gulersonmez
- Louisa R. Hoes (ORCID: https://orcid.org/0000-0002-6256-3541)
- Emile E. Voest (ORCID: https://orcid.org/0000-0001-8249-9586)
- Ingrid Hofland
Institutions
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Cancer Genomics Centre (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1669
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80