X-linked transcriptome dysregulation across immune cells in systemic lupus erythematosus
Here, we present a comprehensive analysis of X-linked gene expression across immune cells in SLE. Our study highlights the complexity of X-linked transcriptional changes, with distinct patterns observed across both innate and adaptive immune cell types. These findings offer novel insights into the role of the X-transcriptome in sex-biased autoimmune susceptibility and may support future efforts to identify molecular targets relevant to SLE pathogenesis.
Authors
- Ana Rita Grosso (ORCID: https://orcid.org/0000-0001-6974-4209)
- Mafalda Soares
- Paulo Caldas (ORCID: https://orcid.org/0000-0001-6730-4461)
- Simão Teixeira da Rocha (ORCID: https://orcid.org/0000-0002-9683-7942)
- Inês Saraiva Wemans
Institutions
- University of Lisbon (PT)
- Iscte – Instituto Universitário de Lisboa (PT)
- Institute for Biotechnology and Bioengineering (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s13293-025-00750-3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Applied Molecular Biosciences Unit
- Fundação para a Ciência e a Tecnologia