Advancing U.S. Competitiveness in Agentic Gen AI: A Strategic Framework for Interoperability and Governance

The rapid evolution of artificial intelligence has given rise to agentic AI systems—autonomous entities capable of perceiving their environment, making decisions, and executing actions with minimal human intervention. This work provides a systematic analysis of agentic AI frameworks, governance models, and implementation strategies. Drawing on a comprehensive review of the literature, we examine the current state of agentic AI technologies, highlight key challenges in governance, security, and ethical oversight, and compare architectural frameworks for responsible deployment. Our results, illustrated through detailed framework comparisons and governance analyses, demonstrate that while agentic AI holds transformative potential across multiple sectors, notable gaps persist in standardization, regulatory compliance, and interoperability. To address these issues, we propose a layered architecture that embeds governance and security across all system layers. An analysis of the competitive landscape further identifies critical interoperability challenges that could undermine U.S. leadership. Based on these insights, we outline a strategic framework for U.S. competitiveness, emphasizing accelerated standards development, international collaboration, and investment in interoperability research. Finally, emerging trends and future directions are explored to provide a comprehensive roadmap for responsible deployment of agentic AI.