The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial
Low-dose aspirin has no effect in reversing frailty among prefrail and frail individuals. The findings highlight the need to explore alternative anti-inflammatory medications for frailty management.
Authors
- Mark Raymond Nelson (ORCID: https://orcid.org/0000-0001-9941-7161)
- Robyn L. Woods (ORCID: https://orcid.org/0000-0003-1249-6149)
- Michael E. Ernst (ORCID: https://orcid.org/0000-0003-0267-4888)
- Rory Wolfe (ORCID: https://orcid.org/0000-0002-2126-1045)
- Suzanne Gaye Orchard (ORCID: https://orcid.org/0000-0003-0211-3183)
- Aung Zaw Zaw Phyo (ORCID: https://orcid.org/0000-0002-8834-4072)
- Joanne Ryan (ORCID: https://orcid.org/0000-0002-7039-6325)
- Sara Espinoza (ORCID: https://orcid.org/0000-0002-1116-302X)
- Zhen Zhou (ORCID: https://orcid.org/0000-0002-0835-8686)
- Chao Zhu (ORCID: https://orcid.org/0000-0003-3951-7501)
- Peng Qiu (ORCID: https://orcid.org/0009-0007-0332-4165)
- F. Setiawan (ORCID: https://orcid.org/0009-0002-7803-1555)
- Ananta P Handono
Institutions
- University of Iowa (US)
- University of Tasmania (AU)
- University of Indonesia (ID)
- General Department of Preventive Medicine (VN)
- Shanghai Ninth People's Hospital (CN)
- Longevity Biotech (United States) (US)
- South Texas Veterans Health Care System (US)
- Melbourne Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ageing/afaf271
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00