The Relationship between COL5A1 rs12722 Polymorphism and Flexion-Extension Lumbar Spine Range of Motion and Soft Tissue Injuries

Background. Genetics may play a critical role in soft tissue injuries by influencing the level of range of motion. To this end, the aim of the study was to investigate the relationship between the COL5A1 rs12722 gene polymorphism and flexion-extension lumbar spine range of motion and soft tissue injuries Methods. A total of 100 male athletes from elite level bodybuilding, wrestling, artistic gymnastics and football sports branches were included in the present study. Blood samples were taken from athletes to analyze the COL5A1 rs12722 gene polymorphism. Then, with the help of a goniometer, flexion-extension lumbar spine range of motion levels of the athletes were measured. ANOVA, Pearson Chi-Square and Fisher Freeman Halton exact tests were used in the statistical analysis. Results. As a result, it was seen that 30% of the athletes had CC, 46% had CT and 24% had TT genotype. In terms of allele distribution, 53% of athletes had the C allele and 47% had the T allele. There was a statistically significant difference between the COL5A1 rs12722 and flexion lumbar spine range of motion (p < 0.05). On the other hand, there was no statistically significant difference in the other sub-dimensions (p >0.05). Conclusions. In the study, it was concluded that the CC genotype and C allele of the COL5A1 rs12722 polymorphism may be associated with the increased level of range of motion in lumbar spine flexion. In conclusion, due to the increased level of movement, athletes may be significantly protected from soft tissue injuries.