In Silico And In Vivo Evaluation Of 5-Ht1b Receptor Agonist In High Fat Diet-Induced Obese Rats

Aim of the study: To find out 5HT1B receptor agonist with better binding affinity by molecular docking method for anti-obesity activity in rat model of high fat diet induced obesity. Materials and Methods: Molecular docking is a computational method employed to predict the binding mode of a small molecule, such as a ligand or a drug, to a protein or enzyme. In present study, 5 HT1B receptor agonists have been reported to reduce hunger, food intake. Therefore molecular docking of Dihydroergotamine (protein bound), CP94253 (agonist), atorvastatin (standard drug), eletriptan (test drug), almotriptan, rizatriptan, frovatriptan and naratriptan was done by selecting UCSF-Chimera© (version 1.13) software. Results: The docking outcomes showed better binding affinity of the atorvastatin and eletriptanthan other 5HT1Breceptor agonists for antiobesity activity by utilizing high fat diet-induced obesity model.