Clinicopathological and molecular correlates of clinical benefit from disitamab vedotin (RC48), a HER-2-targeting antibody-drug conjugate, in metastatic urothelial carcinoma: a multi-center, real-world study
In conclusion, patients with higher HER-2 expression, positive responses to chemotherapy, or elevated TMB are more likely to benefit from DV. These discoveries support the rationale for employing HER-2 antibody-drug conjugates (ADCs) for mUC patients.
Authors
- Kaifeng Jin (ORCID: https://orcid.org/0000-0001-9867-6516)
- Jingtong Xu (ORCID: https://orcid.org/0009-0007-5041-5860)
- Zhaopei Liu (ORCID: https://orcid.org/0000-0002-5288-5037)
- Yawei Ding (ORCID: https://orcid.org/0000-0002-2879-3642)
- Jiejie Xu (ORCID: https://orcid.org/0000-0001-7431-9063)
- Xiaohe Su (ORCID: https://orcid.org/0009-0006-4951-2236)
- Han Zeng (ORCID: https://orcid.org/0000-0001-6486-2038)
- Yuan Chang (ORCID: https://orcid.org/0000-0003-1125-4041)
- Le Xu (ORCID: https://orcid.org/0000-0002-7910-3357)
- Hailong Liu (ORCID: https://orcid.org/0000-0002-6181-2577)
- Yu Zhu
- Z. Xu (ORCID: https://orcid.org/0000-0001-8634-520X)
- Zewei Wang (ORCID: https://orcid.org/0009-0002-0378-1474)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1186/s12885-025-14870-x
- Citations
- 2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Gilead Sciences
- Natural Science Foundation of Shanghai
- Shanghai Anti-Cancer Association
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Education Development Foundation
- Fudan University
- Shanghai Municipal Education Commission
- Shanghai Municipal Health Bureau
- Army Medical University