Association between type 2 diabetes mellitus and bone mineral density in postmenopausal Nigerian women: a multicenter cross-sectional study

Type 2 diabetes mellitus (T2DM) and osteoporosis are intersecting non-communicable diseases disproportionately affecting postmenopausal women, particularly in low- and middle-income countries. Despite increasing global recognition of diabetes-related bone fragility, data from sub-Saharan Africa remain limited. This study examined the association between T2DM and bone mineral density (BMD) in postmenopausal women attending tertiary hospitals in Nigeria, with emphasis on prevalence, self-care practices, and associated risk factors. A hospital-based cross-sectional study was conducted across 12 tertiary hospitals in Nigeria between June 2024 and March 2025. A total of 586 postmenopausal women aged ≥ 60 years were surveyed using the Diabetes Mellitus and Bone Mineral Density Assessment Questionnaire (DMBMDAQ). BMD was assessed using DEXA scans. Descriptive statistics and chi-square tests were employed, with significance set at p ≤ 0.05. Of the participants, 71.3% had T2DM, and 62.5% had abnormal BMD. T2DM was significantly associated with low BMD (p = 0.001; OR = 0.241, 95% CI: 0.812–0.921). Only 27% adhered consistently to medications, and 41.9% achieved good glycemic control. Physical inactivity, abnormal BMI, and inadequate calcium intake were prevalent. Despite 66.4% undergoing DEXA scans, only 37.5% had normal BMD. T2DM is significantly associated with reduced BMD among Nigerian postmenopausal women. Although awareness and supplement use exist, self-care adherence remains inadequate. Integrated approaches involving screening, education, and lifestyle interventions are essential to mitigate this dual burden in aging populations.

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Journal
Discover Medicine
Published
2025-09-25
DOI
https://doi.org/10.1007/s44337-025-00459-7
Primary Topic
Bone health and osteoporosis research
Type
article
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article

Association between type 2 diabetes mellitus and bone mineral density in postmenopausal Nigerian women: a multicenter cross-sectional study

Uchenna Cosmas Ugwu, Osmond Chukwuemeka Ene, Agatha Nneka Obayi, Olive Oluchukwu Ilo
Discover Medicine
Bone health and osteoporosis research
article

Association between type 2 diabetes mellitus and bone mineral density in postmenopausal Nigerian women: a multicenter cross-sectional study

Uchenna Cosmas Ugwu, Osmond Chukwuemeka Ene, Agatha Nneka Obayi, Olive Oluchukwu Ilo
article en

Abstract

Type 2 diabetes mellitus (T2DM) and osteoporosis are intersecting non-communicable diseases disproportionately affecting postmenopausal women, particularly in low- and middle-income countries. Despite increasing global recognition of diabetes-related bone fragility, data from sub-Saharan Africa remain limited. This study examined the association between T2DM and bone mineral density (BMD) in postmenopausal women attending tertiary hospitals in Nigeria, with emphasis on prevalence, self-care practices, and associated risk factors. A hospital-based cross-sectional study was conducted across 12 tertiary hospitals in Nigeria between June 2024 and March 2025. A total of 586 postmenopausal women aged ≥ 60 years were surveyed using the Diabetes Mellitus and Bone Mineral Density Assessment Questionnaire (DMBMDAQ). BMD was assessed using DEXA scans. Descriptive statistics and chi-square tests were employed, with significance set at p ≤ 0.05. Of the participants, 71.3% had T2DM, and 62.5% had abnormal BMD. T2DM was significantly associated with low BMD (p = 0.001; OR = 0.241, 95% CI: 0.812–0.921). Only 27% adhered consistently to medications, and 41.9% achieved good glycemic control. Physical inactivity, abnormal BMI, and inadequate calcium intake were prevalent. Despite 66.4% undergoing DEXA scans, only 37.5% had normal BMD. T2DM is significantly associated with reduced BMD among Nigerian postmenopausal women. Although awareness and supplement use exist, self-care adherence remains inadequate. Integrated approaches involving screening, education, and lifestyle interventions are essential to mitigate this dual burden in aging populations.

Discover MedicineVol. 2(1)
University of Nigeria (NG)
Openalex Percentile: Top 66%
Bone health and osteoporosis research
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Association between type 2 diabetes mellitus and bone mineral density in postmenopausal Nigerian women: a multicenter cross-sectional study — Uchenna Cosmas Ugwu, Osmond Chukwuemeka Ene, et al. · Discover Medicine (2025) | TGRS Research Map | TGRS