Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib
Veliparib improved functional outcome in aging mice. Because ischemic stroke predominantly occurs in the aging population, further research into the benefit of PARP inhibitors in aged animal models of stroke is warranted.
Authors
- Kazi Akhter (ORCID: https://orcid.org/0009-0001-6390-183X)
- Raymond C. Koehler (ORCID: https://orcid.org/0000-0002-5890-9992)
- Sofia Velazquez (ORCID: https://orcid.org/0000-0001-5954-3518)
- Rakesh B. Patel (ORCID: https://orcid.org/0000-0001-9727-9738)
- Ali S. Arbab (ORCID: https://orcid.org/0000-0003-2902-3671)
- Lauren Hachmann Sansing (ORCID: https://orcid.org/0000-0002-6898-1680)
- Jaroslaw Aronowski (ORCID: https://orcid.org/0000-0002-9256-7973)
- Ted M. Dawson (ORCID: https://orcid.org/0000-0002-6459-0893)
- Krishnan M. Dhandapani (ORCID: https://orcid.org/0000-0001-7044-1117)
- Yanrong Shi (ORCID: https://orcid.org/0000-0002-3144-5569)
- Valina L. Dawson (ORCID: https://orcid.org/0000-0002-2915-3970)
- Jessica Lamb (ORCID: https://orcid.org/0000-0002-0342-9983)
- Louise D. McCullough (ORCID: https://orcid.org/0000-0002-8050-1686)
- Lidiya Obertas
- Anil Kumar Chauhan (ORCID: https://orcid.org/0000-0001-8554-0898)
- Andrew Goh
- Mariia Kumskova (ORCID: https://orcid.org/0000-0002-2477-3011)
- Mohammad Badruzzaman Khan (ORCID: https://orcid.org/0000-0001-8231-1256)
- Cenk Ayata (ORCID: https://orcid.org/0000-0002-3644-6042)
- Pradip Kumar Kamat (ORCID: https://orcid.org/0000-0002-0376-2284)
- Daniel R. Thedens (ORCID: https://orcid.org/0000-0002-4704-3185)
- Steven Lannon
- David Charles Hess (ORCID: https://orcid.org/0000-0002-8345-9153)
- Xuyan Jin (ORCID: https://orcid.org/0009-0003-1923-4923)
- Mu‐Hsun Chen (ORCID: https://orcid.org/0000-0002-5111-1582)
- Márcio A. Diniz (ORCID: https://orcid.org/0000-0002-2427-7843)
- Hannah E. Beatty (ORCID: https://orcid.org/0000-0002-0077-0270)
- Sebastián Díaz-Pérez (ORCID: https://orcid.org/0000-0002-3048-9906)
- Enrique C. C Leira (ORCID: https://orcid.org/0000-0003-3695-2946)
- Ken Arai (ORCID: https://orcid.org/0000-0003-1615-3258)
- Jelena Mihailovic (ORCID: https://orcid.org/0000-0002-1608-0637)
- Karni Bedirian
- Klaus van Leyen (ORCID: https://orcid.org/0000-0003-1032-3754)
- Lígia Simões Braga Boisserand (ORCID: https://orcid.org/0000-0002-0058-2894)
- Senthilkumar S. Karuppagounder (ORCID: https://orcid.org/0000-0002-3281-9913)
- Takahiko Imai (ORCID: https://orcid.org/0000-0002-4422-2946)
- Taylan Denis Erdogan
- Nirav Dhanesha (ORCID: https://orcid.org/0000-0001-9268-4363)
- Andreia Morais (ORCID: https://orcid.org/0000-0002-9351-2552)
- Jonah Patrick Weigand Whittier
- Suyi Cao (ORCID: https://orcid.org/0000-0002-0230-1232)
- Fahmeed Hyder (ORCID: https://orcid.org/0000-0001-7822-4002)
- Patrick D. Lyden (ORCID: https://orcid.org/0000-0001-6170-4042)
- W. Taylor Kimberly (ORCID: https://orcid.org/0000-0002-2519-8530)
- Basavaraju G. Sanganahalli (ORCID: https://orcid.org/0000-0002-0851-6621)
- Alison L. Herman (ORCID: https://orcid.org/0000-0002-5824-3924)
- Eng H. Lo (ORCID: https://orcid.org/0000-0002-9327-2915)
- Brooklyn D. Avery (ORCID: https://orcid.org/0009-0009-7093-7580)
- Emma Immakavar
- Lili Yu (ORCID: https://orcid.org/0000-0001-5832-1024)
- Kai Wang (ORCID: https://orcid.org/0000-0003-0567-3004)
- Anjali Chauhan (ORCID: https://orcid.org/0000-0002-9825-8100)
- Mohammad Nisar (ORCID: https://orcid.org/0000-0001-5255-6009)
- Tao Qin (ORCID: https://orcid.org/0009-0006-2511-8373)
- Cameron Smith (ORCID: https://orcid.org/0000-0003-4865-0179)
- Conor Johnson
- Shuning Huang
- Shahneela Siddiqui
- Joseph B. Mandeville
- Karisma A. Nagarkatti
- MD Jaroslaw Aronowski
Institutions
- University of Southern California (US)
- University of Iowa (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Augusta University (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1161/jaha.124.040914
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00