Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib

Veliparib improved functional outcome in aging mice. Because ischemic stroke predominantly occurs in the aging population, further research into the benefit of PARP inhibitors in aged animal models of stroke is warranted.

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Publication Details

Journal
Journal of the American Heart Association
Published
2025-09-25
DOI
https://doi.org/10.1161/jaha.124.040914
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
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article

Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib

Kazi Akhter, Raymond C. Koehler, Sofia Velazquez, Rakesh B. Patel et al.
Journal of the American Heart Association
PARP inhibition in cancer therapy
article

Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP‐Ribose) Polymerase Inhibitor Veliparib

Kazi Akhter, Raymond C. Koehler, Sofia Velazquez, Rakesh B. Patel, Ali S. Arbab, Lauren Hachmann Sansing, Jaroslaw Aronowski, Ted M. Dawson, Krishnan M. Dhandapani, Yanrong Shi, Valina L. Dawson, Jessica Lamb, Louise D. McCullough, Lidiya Obertas, Anil Kumar Chauhan, Andrew Goh, Mariia Kumskova, Mohammad Badruzzaman Khan, Cenk Ayata, Pradip Kumar Kamat, Daniel R. Thedens, Steven Lannon, David Charles Hess, Xuyan Jin, Mu‐Hsun Chen, Márcio A. Diniz, Hannah E. Beatty, Sebastián Díaz-Pérez, Enrique C. C Leira, Ken Arai, Jelena Mihailovic, Karni Bedirian, Klaus van Leyen, Lígia Simões Braga Boisserand, Senthilkumar S. Karuppagounder, Takahiko Imai, Taylan Denis Erdogan, Nirav Dhanesha, Andreia Morais, Jonah Patrick Weigand Whittier, Suyi Cao, Fahmeed Hyder, Patrick D. Lyden, W. Taylor Kimberly, Basavaraju G. Sanganahalli, Alison L. Herman, Eng H. Lo, Brooklyn D. Avery, Emma Immakavar, Lili Yu, Kai Wang, Anjali Chauhan, Mohammad Nisar, Tao Qin, Cameron Smith, Conor Johnson, Shuning Huang, Shahneela Siddiqui, Joseph B. Mandeville, Karisma A. Nagarkatti, MD Jaroslaw Aronowski
article en

Abstract

Veliparib improved functional outcome in aging mice. Because ischemic stroke predominantly occurs in the aging population, further research into the benefit of PARP inhibitors in aged animal models of stroke is warranted.

Journal of the American Heart AssociationVol. 14(19)
University of Southern California (US), University of Iowa (US), Harvard University (US), Johns Hopkins University (US), Augusta University (US), Yale University (US), Massachusetts General Hospital (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 64%
PARP inhibition in cancer therapy
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