Effect of Phenylephrine on Cerebrovascular Regulation: A Translational Perspective
Neither systemic nor intracarotid phenylephrine infusion compromised cerebral perfusion, possibly related to increased endothelial NO signaling and reduced α1R density in downstream pial arteries.
Authors
- T. Dylan Olver (ORCID: https://orcid.org/0000-0003-1263-680X)
- Corey R. Tomczak (ORCID: https://orcid.org/0000-0002-8182-6466)
- Erika M. Boerman (ORCID: https://orcid.org/0000-0001-8103-3485)
- Michael M. Tymko (ORCID: https://orcid.org/0000-0001-9945-339X)
- Jaume Padilla (ORCID: https://orcid.org/0000-0002-7944-4936)
- Ryan L. Hoiland (ORCID: https://orcid.org/0000-0002-5657-0059)
- Adam M.S. Luchkanych (ORCID: https://orcid.org/0009-0003-0201-0528)
- Cameron J. Morse (ORCID: https://orcid.org/0000-0001-7120-0745)
- Craig A. Emter (ORCID: https://orcid.org/0000-0003-1251-591X)
- Mypinder S. Sekhon (ORCID: https://orcid.org/0000-0002-4487-301X)
- Gabriela Delgado (ORCID: https://orcid.org/0000-0003-2947-7796)
- Jude S. Morton (ORCID: https://orcid.org/0009-0004-7572-7041)
- M. H. Laughlin
- Breanna Barlage
Institutions
- University of British Columbia (CA)
- Missouri College (US)
- University of Saskatchewan (CA)
- Department of Physiological Sciences (RU)
- University of Missouri (US)
- University of Guelph (CA)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1161/jaha.125.042396
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.16